Wesley's autopsy pictures


Chest cavity.
Wesley

Chest cavity.
Wesley

Chest cavity right lung (or what was left over).
Wesley

Chest cavity right lung (or what was left over).
Wesley

Chest cavity right lung (or what was left over).
Wesley

Bit of right lung (I think).
Wesley

Bit of right lung (I think).
Wesley

Heart.
Wesley

Heart.
Wesley


Wesley's histopathlogy report

Diagnosis
Bacterial bronchopneumonia

Prognosis
Not Applicable

Histopathology Report

Sections from necropsy samples of multiple tissues from a 5.5-year-old, neutered male ferret, were examined microscopically.

LIVER: 1 sample received; 1 section examined. Microscopy reveals fairly marked sinusoidal congestion, otherwise this sample is largely unremarkable.

KIDNEY: 2 samples received; 2 sections examined. Like the liver, both kidneys are markedly congested. Microscopy additionally reveals moderate to marked thickening of glomerular capillary basement membranes, but there is minimal accompanying inflammation and no tubular proteinaceous casts.

SPLEEN: 1 sample received; 1 section examined. The splenic pulp is moderately expanded owing to a combination of congestion and moderate extramedullary haemopoiesis.

LUNG: 1 sample received; 1 section examined. Microscopy reveals severe, necrotizing, purulent bronchopneumonia and pleuritis. The mainstem bronchus is filled with partly necrotic, purulent exudate containing abundant filamentous, Gram-negative bacteria. The wall of the bronchus has been destroyed by the inflammation in places and inflammation extends throughout the pulmonary parenchyma. There is widespread alveolar flooding and haemorrhage. A thick layer of fibrino-necrotic material is present on the pleural surface, with underlying inflammatory exudate.

HEART: 1 sample received; 2 sections examined. There is moderate fibrosis and congestion of the papillary muscles, but the remainder of the myocardium is largely normal. A very mild inflammatory infiltrate is present in the epicardium.

SMALL INTESTINE: 1 sample received; 1 section examined. This is histologically unremarkable.

LARGE INTESTINE: 1 sample received; 1 section examined. Possibly slightly higher than normal numbers of mainly mononuclear leucocytes are present in the lamina propria, otherwise this is histologically unremarkable.

PANCREAS: 2 samples received; 2 sections examined. One of these is histologically unremarkable, apart from moderate autolytic damage. The other contains a small, encapsulated islet cell adenoma (aka insulinoma).

ADRENAL GLAND: 2 samples received; 2 sections examined. There is mild cortical hyperplasia In both of these adrenal glands.

LYMPH NODE: 3 samples received; 3 sections examined. These are congested, haemorrhagic and oedematous but show minimal lymphoid activity.

ADIPOSE TISSUE: 1 sample received; 1 section examined. This is mildly haemorrhagic, but in the absence of other accompanying pathological changes (inflammation, fibrosis etc.) this may well be post-mortem artefact.

DIAGNOSIS: Bacterial bronchopneumonia.

DISCUSSION: The cause of death was evidently severe, bacterial, bronchopneumonia. Several other changes were also identified in the tissues, including mild adrenal cortical hyperplasia and a small pancreatic islet cell tumour - common findings in middle-aged and older ferrets, but of questionable significance in this case. There is also evidence of membranous glomerulonephropathy - perhaps, but not unequivocally, an immune-mediated phenomenon secondary to the inflammation in the lungs. Congestion in the liver, kidneys and lymph nodes was probably agonal.


Wesley's bacterial swab

Aerobic and anaerobic culture and sensitivity

Organism Isolated Non-haemolytic Streptococcus Bacillus spp Bacteroides spp
  Isolate 1 from Swab Isolate 2 from Swab Isolate 1 from Swab
       
Organism Type Aerobic Aerobic Anaerobic
Growth Rate Scanty Scanty Moderate
       
Enrofloxacin     Sensitive
Tetracyclin     Sensitive
Sulphamet/Trimethop     Resistant
Amoxy/Clav.Acid     Sensitive
Clindamycin     Sensitive
Cephalexin     Sensitive
Marbofloxacin     Sensitive
Metronidazole     Sensitive

Laboratory comments

No further pathogens Isolated after prolonged culture.

Pathology comments

Non-haemolytic streptococci are found on the mucous membranes and skin of healthy animals and if isolated from diseased tissue are usually regarded as contaminants or unimportant secondary invaders.

Bacillus species are numerous and are widely distributed in air, soil and water. While there are some highly pathogenic bacilli (e.g. B. anthracis, B. cereus), the majority of the Bacillus species have little or no pathogenic potential and occur simply as commensals on the animal.

Bacteroides spp are Gram-negative, obligate anaerobes that comprise one of the most numerous constituents of the vertebrate intestinal flora. They are also abundant in the oral cavity, where they are usually held in check by the host defences, but under appropriate circumstances they can become pathogenic, so it is possible that this isolate is aetiologically significant.