Squirt's autopsy pictures

Exploratory preparation

Exploratory preparation

Exploratory preparation

Abdominal fluid

Mesentery, see histopathology report

Stomach & mesentery

Abdominal fluid

Stomach & mesentery & spleen


Stomach & mesentery & liver growth

Stomach & mesentery & liver growth

Pancreatic nodule


Poss burst cyst on mesentery

Spleen, stomach & mesentery & liver growth

Liver growth & small tissue sample of mesentery

Liver growth

Squirt's histopathlogy report

Diagnosis Pancreatic Exocrine Carcinoma and Metastasis
Prognosis Suggested Diagnosis - Please See Comments

Histopathology Report

Sections from necropsy samples of various tissues from a 5-year-old, male, Ferret were examined microscopically.

LIVER: 1 sample received; 1 section examined. This sample contains only a narrow rim of viable, recognizable hepatic tissue along one edge, although the sinusoids are markedly distended and the hepatocytic cords slightly atrophied in appearance. Approximately one third of the sample is unrecognizable necrotic tissue, while the remainder comprises part of a highly cellular neoplasm composed of medium-sized, polyhedral cells predominantly arranged as more or less solid sheets, but occasionally forming distinct acinar or ductular structures. There is little nuclear atypia, but the mitotic index is high (frequently in excess of ten per single high power field). A moderate amount of inflamed, proliferative fibrovascular tissue is present on the capsule covering some of the necrotic part of the sample.

PANCREAS: 1 sample received; 1 section examined. Lobules of relatively normal pancreatic tissue surround a smallish neoplastic mass, approximately 4mm in diameter on the slide, which is histologically similar to the neoplastic tissue seen in the liver, only with acinar/ductular structures more prominent and surrounded by a dense fibrous capsule.

LYMPH NODE: 1 sample received; 1 section examined. This is somewhat enlarged chiefly as a result of oedema, with pronounced dilatation of the medullary and subcapsular sinuses, but there is no evidence of neoplasia within this node.

MESENTERY: 1 sample received; 1 section examined. This sample contains a large amount of moderately inflamed, reactive fibrous tissue, in one place forming a reasonably discrete nodule with necrotic centre, but a cause is not apparent in the sections examined. There is no overt evidence of neoplasia here.

DIAGNOSIS: Pancreatic carcinoma with metastasis to the liver.

DISCUSSION: Histopathological evaluation of these tissues confirms a pancreatic carcinoma with metastasis to the liver. The morphology of the neoplastic tissue is not typical of an endocrine (islet cell) carcinoma and the presence of distinct acinus-like structures in the neoplastic tissue, both in the pancreas and the liver, suggests this is an exocrine carcinoma; however, there are no convincing zymogen granules within the neoplastic cells, not in itself unusual, but making it difficult to rule out the alternative possibility of a pancreatic duct carcinoma.

The inflammatory changes in the mesentery are most likely a reaction to similar changes on the hepatic capsule due to the presence of the tumour and are themselves probably responsible for the oedema in the lymph node.