Riley's autopsy pictures


Autopsy was performed approx. 7 hours after death.


Riley

Pancreas with cyst.




Riley

Expanded, gas filled stomach, mottled spleen above.




Riley

Blood filled liver.




Riley

Kidney (with burst? cyst).




Riley

Kidney again.




Riley

Chest cavity with heart.




Riley

Heart.




Riley

Heart.




Riley

Heart.





Blood test values from 30.03.06

Haematology

PLT Flags: SCH MIC
WBC: 4.6 10^3/mm^3 (2.5-5.5)
RBC: 12.88 10^6/mm^3 (6.50-12.00)
HGB: 23.0 g/dl (15.0-18.0)
HCT: 76 % (40.0-60.0)
PLT: 840 10^3/mm^3 (300-900)
MCV: 118 um^3 (45-65)
MCH: 34.18 pg (15.0-20.0)
MCHC: 60.6 g/dl (30.0-34.0)
RDW: 24.2 % (14.0-17.0)
MPV: 20.4 um^3 (6.7-11.1)

DIFF:
%LYM 48.2 % (12.0-50.0)
%MON 20.0 % (0.0-6.0)
%GRA 130.18 % (15.0-80.0)
#LYM 1.0 10^3/mm^3 (0.3-1.3)
#MON 0.4 10^3/mm^3 (0.0-0.2)
#GRA 3.2 10^3/mm^3 (0.4-2.0)

Biochemistry

ALB= 35 g/l (26-38)
ALKP= 46 U/L (9-84)
ALT= 54 U/L (82-289)
AMYL= 25 U/L
Ca= 2.29 mmol/l (2.00-2.95)
CHOL= 3.91 mmol/l (1.65-7.65)
CREA= 48 umol/l (35-80)
GLU= 6.00 mmol/l (5.22-11.50)
PHOS= 1.67 mmol/l (1.55-2.87)
TBIL< 2 umol/l (2-17)
TP= 69 g/l (52-73)
UREA= 12.2 mmol/l (3.6-16.1)
GLOB= 34 g/l (18-31)


Riley's pathology report:


HISTORY
All organs - ferret postmortem. Signs of cardiac failure. Mild hyperglobulinaemia. (LTF).


Diagnosis
Pericarditis

Prognosis
Prognosis Not Applicable


HISTOLOGIC FINDINGS

Several tissues from a pole cat male neutered ferret are examined (4 slides, 11 tissues). There is mild postmortem change (autolysis) and good preservation of the tissues.
In the lamina propria of the small intestine, there are small numbers of plasma cells and eosinophils (within normal limits).

There is severe congestion of the liver and adrenal medulla. There is a focus of adrenocortical cells present in the mesenteric adipose tissue next to one of the adrenal glands (slide 2).

The spleen has a focus of hemorrhage at one edge of the section examined. The rest of the parenchyma has multifocal congestion and a prominent white pulp with common hematopoietic tissue.

The pulmonary parenchyma is diffusely collapsed (artifactual compression). There is diffuse and marked congestion of the alveolar capillaries and a few scattered macrophages filled with brown-green vacuoles that become blue with Perl's stain (interpreted as hemosiderophages, also known as heart failure cells). There is one bronchus that contains a dense plug of eosinophilic mucus with some lymphocytes. Lymphocytes are also present in peribronchial regions, in moderate numbers.

In the heart, there is a cluster of polygonal cells with abundant cytoplasm admixed with fibrinous debris located in the pericardial space between the base of the aorta and the left atrial epicardial surface (macrophages). There are clusters of lymphocytes and occasional plasma cells along the epicardial and pericardial surface. A trichrome stain does not highlight any increased fibrous tissue in the right ventricular free wall as compared with the left one.

There are few mineral calculi in the medulary tubules of both kidneys. Occasional glomeruli are sclerotic.

In the mesentery adjacent to the pancreas there is a large area of adipose tissue necrosis surrounded by a rim of lymphocytes. These focus actually compresses the adjacent pancreatic parenchyma.

COMMENTS:
There is some evidence to support a mild or acute heart failure in this ferret, but it is not conclusive (heart failure cells in the lung). There is a histiolymphocytic pericarditis and lymphoid clusters in the mesentery and the epi/pericardium. The lymphoid aggregates are commonly found in cases of parvovirus infection in ferrets (aleutian disease), thus supporting your clinical diagnosis.